"She was a source of joy during our time in Washington and in Dallas," Bush said in a statement issued from his Dallas home.
Miss Beazley and the Bushes' first Scottish terrier, Barney, were highly visible pets at the Bush White House and were featured in a White House Christmas video in 2005 called "A Very Beazley Christmas."
"She was a close companion to her blood relative, Barney. And even though he received all the attention, Beazley never held a grudge against him. She was a guardian to our cats, Bob and Bernadette, who - like Laura and I -- will miss her," Bush said.
Bush gave Miss Beazley as a puppy to Laura on her birthday in 2005.