Two people were killed and as many as 50 injured Thursday in a wreck involving two school buses, a semi and an SUV about 40 miles outside of St. Louis, Missouri, authorities said. Jorma Duran, a spokesman for the Missouri Department of Transportation, said the wreck happened between 10:15 a.m. and 10:30 a.m. at mile marker 250 of I-44. CNN affiliate KTVI reported the two school buses involved in Thursday's crash were carrying high school band students from the St. James (Missouri) School District who were on their way to a Six Flags amusement park in Eureka. Thirty-six of the children aboard the buses were being transported to the SSM Cardinal Glennon Children's Medical Center in St. Louis, a spokeswoman for that facility said. Four others were taken to St. John's Mercy Medical Hospital in Washington, Missouri, and five were transported to St. John's Mercy Medical Center in St. Louis, a spokesman for both hospitals said. St. Louis Children's Hospital spokeswoman Jackie Ferman said one person was taken there. Duran said the crash closed about 4 miles of the eastbound side of the interstate. Video from the scene showed a school bus resting atop the back end of a tractor trailer and another school bus nearby. Since then, video showed a crane removing one of the buses from the tangled wreck. The accident reportedly happened on I-44 in Gray Summit, which is about 40 miles southwest of St. Louis. The Franklin County Sheriff's Office told CNN that it was helping the Missouri State Highway Patrol respond to the wreck.