More than 20 people died when a train crashed into a pick-up truck and a minibus near Cairo, state newspaper al-Ahram said on its website early on Monday.
The train, coming from Bani Swaif, crashed at a crossing near the Giza district, al-Ahram said, without giving further details.
"We are still investigating the incident and once we are done we will issue a statement," an interior ministry source told Reuters.
Egypt's transport network has come under attack last year when fifty people, mostly children, were killed after a train crashed into a school bus South of Cairo.
Roads and railways in Egypt have a poor safety record and locals have long complained that successive governments have failed to enforce even basic safeguards, leading to a string of deadly crashes.
The country's worst train disaster was in 2002 when a fire ripped through seven carriages of an overcrowded passenger train, killing at least 360 people.
Egypt's interim government, appointed after the army ousted the country's first elected President Mohamed Mursi on July 3, announced plans to improve transportation as part of a 29.6 billion Egyptian pound ($4.30 billion)stimulus package.