Haitian Prime Minister Garry Conille submitted his resignation Friday, President Michel Joseph Martelly announced.
Conille just assumed the position in October after being ratified by the country's Senate. His reasons for stepping down were not immediately clear.
Martelly's two previous prime ministerial nominees-- businessman Daniel Rouzier and lawyer Bernard Gousse -- had been rejected by the Haitian Senate. The inability to form a working government raised concerns about Haiti's ability to move forward after a devastating earthquake in January 2010.
Conille, a former United Nations development specialist, served as chief of staff for former President Bill Clinton when the latter served as special U.N. envoy in Haiti.
In that role, he was involved in international aid delivery to Haiti following the earthquake.
In a post on his official Facebook page, Martelly said only that his office received Conille's resignation.
Martelly is expected to address the nation Friday evening.
Conille, a gynecologist, earned a master's degree in health administration from the University of North Carolina at Chapel Hill. He worked for the U.N. Development Program and is a protege of economist Jeffrey Sachs, director of The Earth Institute at Columbia University.
When he assumed the position in October, Conille was welcomed in many corners as someone knowledgeable about development challenges with experience in working with the global community.
The United Nations estimates the 2010 earthquake affected nearly 3 million people and killed about 220,000. More than 1.5 million people were left homeless in a country that was already the poorest in the Western hemisphere and wracked by crisis.