Prime Minister Wael Halki said on Saturday Syrian government forces were winning the war with rebels and would not rest while a single enemy fighter remained at large.
Maintaining Syria's unyielding response to Western calls for President Bashar al-Assad to step aside, Halki said the era of "threats and intimidation has gone, never to return, while the era of victory and pride is being created now on Syrian soil".
He was speaking during a visit to Iran, which has provided military support and billions of dollars in economic aid to Assad during a 2-1/2-year-old civil war which has killed 100,000 people and shows little sign of being halted by diplomacy.
The United Nations said on Monday that a long-delayed "Geneva 2" peace conference would go ahead on January 22. The government and the political opposition have both said they will attend, but rebel fighters on the ground have scorned the talks.
Assad, whose forces have consolidated their hold around Damascus and central Syria this year, faces little internal pressure to make concessions to his opponents as long as he maintains military momentum and Iranian support.
"The Syrian government will not allow a single terrorist on Syrian territory," Halki told Iran's First Vice-President Eshaq Jahangiri, according to Syria's state news agency SANA.
Jahangiri replied that Iran stood "in the same trench alongside Syria, supporting it at all levels against the aggressive axis of evil" aligned against Damascus, SANA said.
Iran has sent military commanders to Syria to help Assad's army, which is also bolstered by the pro-Iranian Lebanese Hezbollah militia and Iraqi Shi'ite fighters. They are battling rebels whose ranks are swollen by an influx of Sunni Islamist fighters from across the Muslim world.
The size of Halki's delegation, which included Syria's energy, electricity, health and foreign ministers, reflected the importance of the alliance between the two countries.
SANA said they discussed activating Iran's multi-billion dollar credit facility to Damascus, bringing Iranian companies back to Syria's war-ravaged economy and speeding up deals to provide oil products, medical equipment and food.
Assad's forces, backed by Hezbollah and local militia, have been fighting to secure the mountainous Qalamoun region overlooking the main highway north of Damascus to the central city of Homs and Assad's Alawite heartland on the Mediterranean.
Activists said warplanes bombarded targets around Nabak, the main town on the road which is outside government control, dropping bomblets on parachutes which ignited fires.
"So far we have three martyrs in Nabak," said a local pro-rebel activist, speaking by Skype, who identified himself only as Abu Rakan. "In Rima, between Yabroud and Nabak, MiG and Sukhoi planes have carried out eight bombing raids."
SANA said the army had "eliminated a number of terrorists in Nabak and the surrounding area", and it also made gains in rebel districts to the east of Damascus, a mix of farmland and urban sprawl known as the eastern Ghouta, and suburbs to the south.
Casualties on both sides have been heavy, with Hezbollah losing at least 25 fighters in eastern Ghouta over the last week, according to security sources in Lebanon.
The Syrian Observatory for Human Rights, a British-based monitoring group, said more than 400 people had been killed across Syria since Thursday, many of them in the battles around Ghouta and Qalamoun.
Assad's force recaptured the town of Deir Attiyah on Thursday, a week after losing it in a rebel counter-offensive, but progress has been gradual and sporadic.
"At night we push them back. In the daytime, because of the planes and the air raids, the Free Syrian army retreats slightly but at night they return to their positions," Abu Rakan said.
The Observatory said fighting also erupted on Saturday in the old quarter of the ancient Christian town of Maloula, between Assad's forces and the al Qaeda-linked Nusra Front, which has been at the forefront of fighting around Qalamoun.
Amid the violence, weapons experts from the Organisation for the Prohibition of Chemical Weapons are trying to oversee the elimination of Syria's chemical weapons stockpile.
The United States has offered to destroy the chemicals on a U.S. ship, the OPCW confirmed on Saturday, and is looking for a suitable Mediterranean port where processing can be carried out.
Sigrid Kaag, head of the joint UN-OPCW Syria team, said the mission was striving meet a tough deadline to get the most lethal chemical agents out of Syria by the end of the year.
She told reporters in Damascus the chemical arsenal, located at various sites across Syria, would be packed, sealed and moved to Syria's Latakia port.
"Then it will be transported to other ships by other member states that will send it to ... a U.S. vessel. It will not be (destroyed) in Syrian territorial waters," she said.