At least 4 people have been killed in an attack by US drones in Pakistan's tribal region of Waziristan, officials said.
Security officials said those killed were Taliban militants, but this has not been independently verified.
The missiles struck a house outside the town of Miramshah. Residents told the BBC they were still sifting the rubble for bodies.
Thousands of people - militants and civilians - have died in such attacks.
They are not sanctioned by Pakistan's government and fuel anti-Western sentiment in the country, reports the BBC's Shoaib Hasan in Karachi. The US says they target militants seeking refuge in the tribal areas.
The attack, which struck in the early hours of Saturday, is the third in three days.
It comes after Pakistani and US officials held meetings during the recent Nato summit on Afghanistan in Chicago.
Relations between the two countries had been frosty since 24 Pakistan soldiers were killed in a Nato air strike in November 2011.
Pakistan shut down a key Nato supply route to Afghanistan and demanded an end to the drone attacks following that incident.