The San Francisco 49ers won a fifth straight game on Sunday, crushing the winless Jacksonville Jaguars 42-10 at London's Wembley Stadium.
The 49ers scored touchdowns on their first four possessions to take a commanding 28-0 lead midway through the second quarter.
Quarterback Colin Kaepernick ran for two touchdowns and connected with tight end Vernon Davis on a two-yard touchdown pass as the 49ers improved their record to 6-2.
Running back Frank Gore also had a pair of touchdowns for the reigning NFC champions.
The Jaguars' only touchdown came in the third quarter on a 29-yard pass from quarterback Chad Henne to wide receiver Mike Brown as their record fell to 0-8.
The game was a sell-out with 83,559 fans at Wembley, one of the largest crowds in the NFL this season.
For the first time this year London is hosting two regular season NFL games. In the first, played last month, the Minnesota Vikings defeated the Pittsburgh Steelers.
Next season there will be three NFL contests at Wembley including the Jaguars against the Dallas Cowboys.