World championship leader Marc Marquez claimed pole position for Sunday's Indianapolis MotoGP while American Ben Spies was ruled out of the race after dislocating a shoulder in practice.
Repsol Honda's Marquez has dominated the weekend's practice sessions and set an Indianapolis pole record with a blistering lap of one minute 37.958 seconds to finish half a second ahead of fellow Spaniard and title rival Jorge Lorenzo of Yamaha.
Their compatriot Dani Pedrosa will start third on the grid for Honda ahead of Britain's Cal Cruchlow of Monster Yamaha.
Seven-times world champion Valentino Rossi, the winner at Indianapolis in 2008, was ninth fastest as the Italian looks for his second victory of the season.
The 20-year-old Marquez enters the 10th race of the campaign with a 16 point advantage over Pedrosa and a 26 point lead over defending world champion Lorenzo.
But there was disappointment for the home crowd on Saturday as Spies, who was returning to action for the first time since his injury in the second race of the year in Texas in April.
Spies was thrown over the front of his bike at turn four in morning practice and his Ignite Pramac Racing team officials said 2009 World Superbike champion had dislocated his shoulder.
Local interest will focus on Ducati's Nicky Hayden, who was sixth fastest in qualifying, and Colin Edwards, who was 12th for NGM Mobile Forward Racing.