The Seattle Seahawks extended their winning start to the season to a franchise record four games after a 23-20 comeback victory in overtime at the Houston Texans on Sunday while the New York Giants suffered a fourth straight loss with a miserable 31-7 defeat at Kansas City.
The defending Super Bowl champions, the Baltimore Ravens also had a tough day with quarterback Joe Flacco throwing five interceptions in a 23-20 loss at Buffalo.
The Seahawks' impressive start to the season looked in danger when they trailed 20-3 in Houston but, helped by some poor choices by Texans quarterback Matt Schaub, Seattle clawed their way back.
Two touchdowns and a pair of field goals in the second quarter had put Houston in charge but Seahawks quarterback Russell Wilson turned on the style in the fourth.
Wilson showed his speed and great footwork on a series of running plays and scrambles, including a crucial fourth and three at the Houston seven-yard line on a 98-yard drive that ended with a three-yard run from Marshawn Lynch.
Still, Houston just needed to eat up the clock but with a seven-point lead and 2:40 on the clock, Schaub attempted to find Owen Daniels but the pass was superbly intercepted by Richard Sherman who ran it in from 58 yards to level the score.
Houston could not score on two possessions in overtime and Steven Hauschka's 45-yard field goal secured the victory for the Seahawks.
"This was an extraordinary day," enthused Seahawks head coach Pete Carroll, who added that his team had refound their personality in the fourth quarter.
"We just wanted to be who we were capable of being and we weren't doing that for a while," he said after his team achieved the best start since entering the league in 1976.
New York Giants head coach Tom Coughlin was in a very different mood after his team's fourth straight loss, describing the second half performance as a "debacle".
The Chiefs, off to a 4-0 start under former Philadelphia Eagles head coach Andy Reid, ran away with the game in the fourth quarter.
Chiefs quarterback Alex Smith, discarded by the San Francisco 49ers last season, threw for 288 yards and three touchdowns while his counterpart Eli Manning was sacked three times and threw one interception.
After a scoreless first quarter, the Chiefs got in front when Sean McGrath collected a five-yard touchdown pass from Smith but the Giants responded with Manning finding Victor Cruz for a 69-yard touchdown.
But the Giants, in a season with the Super Bowl in their home stadium, look to have problems in all areas and Coughlin said he was hoping for a reaction from his veteran players.
"I'm depending heavily on the leadership and character of guys in the locker room...we will have to pick ourselves up and try to improve on the second half debacle here," he said.
Buffalo rookie linebacker Kiko Alonso had two interceptions against Baltimore - the second making sure of the win with 57 seconds left in Orchard Park.
With Aaron Williams also grabbing two picks it was a poor performance from Flacco, the Super Bowl Most Valuable Player last season who will take little consolation from his two touchdown throws and 347 yards passing.